[S28] Intragenomic conflicts and cytonuclear incompatibilities as engines of speciation
This symposium is the result of merging two former independent proposals, "Intragenomic conflicts and speciation" and "The impact of mitonuclear incompatibilities on animal speciation".
Conflicts between genetic elements within an individual for transmission into the next generation are increasingly recognized as powerful drivers of evolutionary change. A by-product of the conflicts and their differential resolution can be negative epistatic interactions causing reduced fitness of hybrids and thus paving the way to speciation. Multiple genes involved in postzygotic reproductive isolation between recently diverged species have experienced bouts of adaptive evolution which cannot be easily linked to ecological selection, but which could result from intragenomic conflict (IC) and selection for its resolution. Also phenotypes of interspecific crosses experiencing asymmetric hybrid breakdown can often be linked to ICs. A major unresolved question is the relative role of ecologically based selection and selection due to ICs in the early stages of speciation. In this symposium we would like to bring together diverse experimental, comparative and theoretical perspectives on the subject.
Many different and essential molecular factories within the cell combine units contributed both by nuclear and organelle genomes. Notwithstanding the functional constraints that operate on those complexes, the independent control of the replication of those genomes anticipates challenging scenarios for the interplay of genetic conflicts, compensatory changes and molecular drive. Mitochondrial and plastid genome variation in natural populations have been traditionally considered as essentially neutral, and accordingly used during the last three decades to reconstruct the history of genetic lineages in a huge number of animal and plant species. Direct evidence of cytonuclear incompatibilities in wild populations is relatively common in plants, but definitely not in animals, which could be particularly hard to analyze in this respect. If mitonuclear incompatibilities in wild animal populations were finally unveiled, it would be necessary to revise the main conclusions of hundreds of papers dealing with phylogeographic patterns in animal species, published in the last 30 years, and the general role of the coevolution of nuclear and organelle genomes in speciation.
Organizers: Wieslaw Babik, Tracey Chapman, Radwan Jacek, Horacio Naveira, Antón Vila-Sanjurjo
Invited speakers: Dan Mishmar, Daven Presgraves