[S19] Evolution of gene expression regulation
More than four decades have passed since it was first suggested that gene expression regulation variation could play a significant role in the phenotypic divergence between chimpanzees and humans. Ever since, there has been an impressive and fruitful effort to characterize the molecular basis of regulatory variation within and between species. However, until recently, ‘regulatory variation’ has been used synonymously with ‘differences in mRNA levels’. In recent years, though, new high-throughput sequencing technologies have offered us a window into fundamental questions about the evolution of post-transcriptional dynamics. With the introduction of methods such as ribosome profiling (RiboSeq) and mass spectroscopy (mass-spec), we can now measure post-transcriptional regulation in a variety of different conditions. These technologies are now being used to study questions from how regulatory variation evolves within and between species. Moreover, there exist exciting avenues in applying these methods to microbial evolution experiments to study how gene expression regulation evolves during adaptation. Other examples include new methods and insights into the evolutionary role of non-coding RNAs, which have been uncovered as key regulators of gene expression at the post-transcriptional level, or the evolution of protein post‐translational modifications that can influence their function, activity or stability. Together, these studies have given us unprecedented insight into the evolution of transcriptional and post-transcriptional regulation. This symposium will bring together researchers that develop and employ high-throughput, quantitative techniques to measure gene expression regulation with the goal of understanding the molecular landscape of complex phenotypes.
Organizers: Oana Carja, Joshua Plotkin, Premal Shah
Inivited speakers: Leonid Kruglyak, Judit Villen